Protein Degradation in Health and Disease. Ciba Foundation Symposium 75 (new series)

plicitly warns that although we have in our hands a powerful tool which can possibly provide clues to some of the questions of how cells function, beyond those problems lies the challenge of how cells aggregate to tissues which, in turn and in concert, become a whole organism. Hans Krebs in a lecture delivered more than 25 years ago shortly after he had been awarded the Nobel Prize for his elegant work elucidating the basic details of intermediary metabolism cautioned the biomedical researcher: to demolish a cell and examine it in its minute detail might in fact be entirely unjustifiable, even to the point of error. This book is about cells, but an analogous warning to those who would extrapolate from cells to the whole organism still holds today. ZOE NAKOS CANELLAKIS Veterans Administration Medical Center and Departments of Pharmacology and Medicine Yale University School of Medicine